Antinuclear antibodies in autoimmune and allergic diseases

Antinuclear antibodies in autoimmune and allergic diseases

Antinuclear antibodies (ANA) are primarily significant in the diagnosis of systemic connective tissue diseases. The relationship between their occurrence in allergic diseases is poorly documented. However, the mechanism of allergic and autoimmune diseases has a common thread. In both cases, an increased production of IgE antibodies and presence of ANA in selected disease entities is observed. E...

Antinuclear antibodies (ANA) in a Colombian cohort of pediatric patients with autoimmune diseases (PAID)

Results 363 patients were included. 66% had JIA, 11% JSLE, 7% juvenile undifferentiated autoimmune disease(JUAD), 4% Scleroderma, 4% JDM, 1% uveitis ANA + and a group of other PAID 11%. ANA positivity varies according to the subtype of JIA from 0-68%. Positive AAN: JSLE 93%, scleroderma 85%, JDM 63%. Most JUAD had ANA + at low titers. A heterogeneous group of other PAID showed a variable titers...

Antiphospholipid Antibodies and Autoimmune Diseases

Antiphospholipid Syndrome (APS) is a common autoimmune disorder in constant evolution. During the last 30 years the clinical and immunological features were established and numerous investigators and clinical practitioners established consensus definition of the diagnostic criteria. The last international experts meeting in Sydney 2006 modified the previous Sapporo criteria. In the autoimmunity...

Antinuclear Antibodies

knowledge of gene regulation, particularly in neoplastic cells, this deficit is striking. With our current understanding of chromosomal translocations, point mutations, and gene amplification in tumor cells, it is surprising to read that there is ". . . no difference between cancer and normal DNA . . ." (p. 130). The author spends a fair amount of time discussing possible mechanisms for the car...

Antinuclear antibodies in systemic sclerosis